Surfactant therapy in meconium aspiration syndrome (MAS)
Meconium aspiration syndrome (MAS) is an important cause of respiratory distress in neonates, sometimes leading to respiratory failure and even death. It is a common problem seen in the delivery room and newborn units. MAS is found in around 2-9% of births and mortality rate is 3-5%. MAS results from aspiration of meconium duringintrauterine gasping or during the first few breaths. There is a significant disturbance of the alveolar surfactant system in MAS as an important element in the pathophysiology of the disease. Therapy for MAS is mainly supportive. But, because of the presence of disturbance in the alveolar surfactant system, administration of exogenous surfactant preparations is recommended. Recently, bronchoalveolar lavage is being recommended.