Vasopressin in myomectomy- effectiveness and its sequelae
J Lalnunnem Thiek, Saswati Sanyal Choudhury, Javed Ali
Objective: The objective of this study is to access the amount of blood loss during myomectomy with and without the use of vasopressin. Methodology: This prospective study conducted from 1st July 2012 to 30th June 2013. Thirty five patients (Group A) received intramyometrial injection of vasopressin during myomectomy whereas similar number of myomectomy was also performed without using vasopressin (Group B). Assessment of blood loss is done by comparing the amount of intra-operative blood loss, postoperative haemoglobin level, need for blood transfusion in the two groups. Results: The mean blood loss in ml in Group A and Group B was 206ml ( SD 105.53) and 493.14ml ( SD 90.05) respectively (p < 0.0001). The post operative mean haemoglobin Group A and B was 10.5gm (SD 1.445) and 9gm ( SD 1.585) respectively and comparison was statistically significant (p value is 0.0056). Both the groups were comparable in regard to the duration of surgery. Two cases in Group A and eight cases in Group B received blood transfusion. Conclusion: Intra-operative blood loss was significantly more in cases where no measure was adopted for controlling blood loss. Use of vasopressin resulted in reduction of blood loss. Significant fall in haemoglobin was observed without the use of vasopressin and fall in haemoglobin was negligible in cases where vasopressin was used.