Impact of maternal serum calcium levels on severity of hypertensive disorder of pregnancy: A cross sectional study
Naina Kumar, Amit Kant Singh
Objectives: Assess relationship between maternal serum calcium levels, severity of disease and overall perinatal and maternal outcome in women with hypertensive disorders of pregnancy. Methods: Present prospective cross sectional study was conducted in the Obstetrics and Gynaecology department of rural tertiary care centre of Northern India after proper Institution ethical committee approval and informed written consent from the participants over a period of seven months (October 2016-May 2017). A total of 110 childbearing women admitted at ≥34 weeks of gestation were divided into three groups; Gestational hypertension (n=35), Pre-eclampsia (n=49) and Eclampsia (n=26). Maternal serum calcium levels and its correlation with severity of disease and overall maternal and perinatal outcome were assessed in each group. Results: Of 110 childbearing women, cases with gestational hypertension had mean serum calcium 8.83 ± 0.55 mg/dl, in pre-eclampsia 8.55 ± 0.89 mg/dl and in eclampsia group 8.41 ± 0.76 mg/dl. Of total 66 term births, 31(88.57%) occurred in gestational hypertension group, 26(53.06%) in pre-eclampsia and 8(30.77%) in eclampsia group. Maximum maternal and perinatal morbidity and mortalities were observed in women with eclampsia having minimum serum calcium levels followed by pre-eclampsia and least in women with gestational hypertension having near normal serum calcium levels. Conclusion: Significant correlation was observed between maternal serum calcium and severity of hypertensive disorder of pregnancy, adverse perinatal and maternal outcome.