ISSN: 2454-2342 (online), 2454-2334 (print)
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The New Indian Journal of OBGYN. 8(1):143-145

Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma

Deval Parekh,Sunaina Wadhwa,Asima Mukhopadhyay,Angad Singh

ABSTRACT

Papillary hidradenoma/ mammary-like gland adenoma (MLGA) is a benign glandular tumor of the vulva. It presents as a mass lesion which often undergoes secondary ulceration and bleeding resembling a malignant tumor. It arises from specialized anogenital glands in the labial folds which resemble mammary glands on microscopy. The tumour shows a tubulo-papillary architecture and is composed of bland columnar cells with apical snouting. GATA-3 is a transcription factor and it’s expression is essential for normal mammary gland development. GATA-3 immunohistochemistry (IHC) is positive in luminal cells of breast and its positive in ductal hyperplasia as well as in breast carcinoma. In summary, we describe a case of a benign vulval mammary gland like adenoma with diffuse GATA-3 expression which was originally diagnosed as a malignant low-grade polymorphous adenocarcinoma and discuss its clinical and associated histopathological findings.

doi: 10.21276/obgyn.2021.8.1.28 Full Text PDF
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