The New Indian Journal of OBGYN. 12(1):193-196

Rise of the dawn - single versus double intrauterine insemination in controlled hyperstimulated cycle in infertile couples

Shinde Shwetambari R, Shastri Shraddha, Damle Hemant

ABSTRACT

Objective: To compare the efficacy of single and double intrauterine insemination for pregnancy rates in infertile couples. Methods: This retrospective study was conducted in tertiary care hospital from January 2015 - December 2020. Patient were given ovulation induction treatment with clomiphene citrate 100mg OD or letrozole 5mg OD daily from day 2 or 3 for 5 days along with inj FSH 75IU (highly purified) was given deep IM on day 5 and day 7. In case of single IUI, it was performed after 36 hours and for double IUI, it was performed after 36 hours and 48 hours after the intramuscular trigger of hCG. Results: Total 250 patients were included in the study, 150 (60%) in single IUI and 100 (40%) in double IUI group. In single IUI group, 24 out of 150 patients conceived (success rate 16%). In double IUI group, out of 100 patients, 21 patients conceived (success rate 21%). There was no statistically significant difference between the two groups. Conclusion: The outcome of double IUI does not give significant benefit compared to single IUI. This increases the stress and disbursement of the couple without actually improving the outcome.