The New Indian Journal of OBGYN. 12(1):83-86

Study of liver function test, renal function test and platelet count in hypertensive disorders of pregnancy

Indrani R, Chandana Ray Das

ABSTRACT

Background: The World Health Organization (WHO) systematically reviews maternal mortality worldwide, and in developed countries, 16 percent of maternal deaths were due to hypertensive disorders. Heightened surveillance permits prompt recognition of ominous changes in blood pressure, critical laboratory findings, clinical signs and symptoms. Objectives: 1) To obtain laboratory values of liver function test, renal function tests, platelet count in hypertensive disorder of pregnancy (HDP). 2) To correlate the obtained laboratory values with the clinical severity among the HDP. Methodology: In this study, total 100 patients attending antenatal OPD and labor room at TMCH having either gestational hypertension (GH), preeclampsia (PE) or eclampsia (E) were included irrespective of age and parity. Their blood sample was collected and sent for laboratory investigations. LFT, RFT, platelet count reports were collected and analysed. Results: Out of 100 study population - 71 cases were primigravida and 29 were multigravida. In liver function tests – total bilirubin was found statistically significant with the mean values 0.54 ± 0.25 in gestational hypertension (GH), 0.62 ± 0.37 in preeclampsia (PE), 0.92 ± 0.36 in eclampsia (E). In renal function tests – blood urea and serum uric acid were statistically significant. Mean value of blood urea was 10.35 ± 3.68 in GH, 14.64 ± 4.98 in PE, 13.92 ± 3.99 in E. Mean value of serum uric acid was 3.41 ± 0.40 in GH, 3.60 ± 0.87 in PE, 4 ± 1.30 in E. Mean values of platelet count was lower in PE (1.30 ± 0.08), E (1.15 ± 0.07) than GH (4.53 ± 2.33). Conclusion: Deranged LFT, RFT, low platelet count aid in diagnosis of HDP and correlate with severity of hypertension, helping in providing better management to both the mother and the baby.